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Our long-term goal is to understand viral pathogenesis at molecular level, especially how viral proteins overcome host defense mechanisms at molecular level in host. At present, our laboratory studies how paramyxovirus parainfluenza virus 5 (PIV5, formerly known as simian virus 5, SV5) and mumps virus proteins inhibit apoptotic pathways. We have been focusing our research effort on interactions between PIV5 small hydrophobic protein (SH) as well as the V protein and host apoptotic pathways. In addition to basic research, we have also been involved in translational research to explore using PIV5 as a vector for gene delivery as well as using apoptosis-inducing recombinant PIV5 as a possible agent for cancer therapy.