Biao He, Ph.D
Associate Professor of Virology
Department of Veterinary & Biomedical Sciences

115 Henning Building
Pennsylvania State University
University Park, PA 16802

Tel: 814-863-8533
Fax: 814-863-6140

Positions:

Publications:

1. He, B., Durbin, R. K. and McAllister, W. T. (1995) Phage RNA polymerase expression vectors that allow efficient expression of cloned genes in both prokaryotic and eukaryotic cells Gene 164, 75-79.
   
   
2. He, B., Rong, M., Lyakhov, D., Gartenstein, H., Diaz, G., Castagna, R., McAllister, W. T. and Durbin, R. K. (1997) Rapid mutagenesis and purification of phage RNA polymerases Protein Expression and Purification 9, 142-151.
   
   
3. He, B., Rong, M., Durbin, R. K. and McAllister, W.T. (1997) A mutant T7 RNA polymerase that is defective in RNA binding and blocked in the early stages of transcription J. Molecular Biology 265, 275-288.
   
   
4. Lyakhov, D., He, B., Zhang, X., Studier, F. W., Dunn, J. J. and McAllister, W. T. (1997) Mutant Bacteriophage T7 RNA polymerases with altered termination properties J. Molecular Biology 269, 28-40.
   
   
5. Lyakhov, D., He, B., Zhang, X., Studier, F. W., Dunn, J. J. and McAllister, W. T. (1998) Pausing and termination by bacteriophage T7 RNA polymerase J. Molecular Biology 280, 201-213.
   
   
6. Rong, M., He, B., McAllister, W. T. and Durbin, R. K. (1998) Promoter specificity determinants of T7 RNA polymerase Proc. Natl. Acad. Sci. U.S.A. 95, 515-519.
   
   
7. He, B., Paterson, R. G., Ward, C. D. and Lamb, R. A. (1997) Recovery of infectious SV5 from cloned DNA and expression of a foreign gene Virology 237, 249-260.
   
   
8. He, B., Kukarin, A. Temiakov, D., Chin-Bow, S. T., Lyakhov, D., Rong, M., Durbin, R. K. and McAllister, W. T. (1998) Characterization of an unusual, sequence-specific termination signal for T7 RNA polymerase J. Biol. Chem. 273, 18802-18811.
   
   
9. He, B., Leser, G. P., Paterson, R. G., and Lamb, R. A. (1998) The Paramyxovirus SV5 small hydrophobic (SH) protein is not essential for virus growth in tissue culture cells Virology 250, 30-40.
   
   
10. He, B., and Lamb, R. A. (1999) Effect of inserting the paramyxovirus SV5 gene junctions at the HN/L gene junction: Analysis of accumulation of mRNAs transcribed from rescued viable viruses J. Virol. 73, 6228-6234.
    
    
11. Pekosz, A., He, B., and Lamb, R. A. (1999) Reverse genetics of negative strand RNA viruses: Closing the circle Proc. Natl. Acad. Sci. U.S.A. 96, 8804-8806.
    
    
12. Schmitt, A. P., He, B., and Lamb, R. A. (1999) Involvement of the cytoplasmic domain of the simian virus 5 hemagglutin-neuramindase protein in paramyxovirus assembly J. Virol. 73, 8703-8712.
    
    
13. Young, D. F., Chatziandreou, N., He, B., Goodbourn, S., Lamb, R. A. and Randall, R. E. (2001) A single amino acid substitution in the V protein of SV5 differentiates its ability to block IFN signaling in human and murine cells J. Virol. 75, 3363-3370.
    
    
14. He, B., Lin, G. Y., Durbin, J. E., Durbin, R. D., and Lamb, R. A. (2001) The SH integral membrane protein of the paramyxovirus SV5 is required to block apoptosis in MDBK cells J. Virol. 75, 4068-79.
    
    
15. He, B., Paterson, R. G., Stock, N., Durbin, J. E., Durbin, R. K., Goodbourn, S., Randall, R. E. and Lamb, R. A. (2002) Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: The multifunctional V protein blocks both interferon-b induction and interferon signaling. Virology,303, 15–32.
    
    
16. Poole, E., He, B., Lamb, R. A., Randall, R. E. and Goodbourn, S. (2002) The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-b. Virology, 303, 33–46.
    
    
17. Lin, Y., Bright, A. C., Rothermel, T. A. and He, B. (2003) Induction of apoptosis by paramyxovirus simian virus 5 lacking small hydrophobic gene. J. Virol. 77(6):3371-83.
    
    
18. Sun, M., Rothermel, T. A., Shuman, L., Aligo, J. A., Xu, S., Lin, Y., Lamb, R. A. and He, B. (2004) The conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis J. Virol. 78(10):5068-78.
    
    
19. Lin, Y., Horvath, F., Aligo, J. A., Wilson, R. and He, B. (2005) The role of simian virus 5 V protein on viral RNA synthesis. Virology. 338(2):270-280.
    
    
20. Wilson, R. L., Fuentes, S. M., Wang, P., Taddeo, E. C., Klatt A., Henderson A. J. and He, B. (2006) Function of small hydrophobic proteins of paramyxovirus . J. Virol. 80(4):1700-9.
    
    
21. Tompkins, S. M., Lin, Y., Leser, G. P., Kramera, K. A., Haas, D. L. , Howerth, E. W., Xu, J., Kennett, M. J., Durbin, R. K., Durbin, J. E., Tripp, R., Lamb, R. A. and He, B. (2007) Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge. Virology. 362(1):139-50.
    
    
22. Fuentes, S., Tran, K. C., Luthra, P., Teng, M. N. and He, B. (2007) Function of the Respiratory Syncytial Virus Small Hydrophobic Protein. J Virol. 2007 Aug;81(15):8361-6.
    
    
23. Tran, K. C., He, B., and Teng, M. N. (2007) Replacement of Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 by the V Protein of Parainfluenza Virus 5. Virology. 2007 Nov 10;368(1):73-82.
    
    
24. Lin, Y., Sun, M. Fuentes, S. M., Keim, C. D., Rothermel, T. and He, B. (2007) Inhibition of Interleukin-6 Expression by the V Protein of Parainfluenza Virus 5. Virology. 2007 Nov 25;368(2):262-72.
    
    
25. Sun, M., Fuentes, S. M., Timani, K., Sun, D., Murphy, C., Lin, Y., August, A., Teng, M. N., He, B. (2008) Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. J Virol. 2008 Jan;82(1):105-14.
    
    

Support:

• American Heart Association
• Pennsylvania Department of Agriculture
• National Institutes of Health
• ACGT