Research

Research Interests:

1. PIV5 & Host Interactions
2. Pathogeniesis of mumps virus
3. Using PIV5 as a Vector for Vaccine Development
4. Testing PIV5 as an oncolytic agent

Recent Publications

1. Sun M, Fuentes SM, Timani K, Sun D, Murphy C, Lin Y, August A, Teng MN, He B. (2008) Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. J Virol. 2008 Jan;82(1):105-14.
   
2. Lin, Y., Sun, M. Fuentes, S. M., Keim, C. D., Rothermel, T. and He, B. (2007) Inhibition of Interleukin-6 Expression by the V Protein of Parainfluenza Virus 5. Virology. 2007 Nov 25;368(2):262-72.
   
3. Tran, K. C., He, B., and Teng, M. N. (2007) Replacement of Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 by the V Protein of Parainfluenza Virus 5. Virology. 2007 Nov 10;368(1):73-82.
   
4. Fuentes, S., Tran, K. C., Luthra, P., Teng, M. N. and He, B. (2007) Function of the Respiratory Syncytial Virus Small Hydrophobic Protein. J Virol. 2007 Aug;81(15):8361-6.
   
5. Tompkins, S. M., Lin, Y., Leser, G. P., Kramera, K. A., Haas, D. L. , Howerth, E. W., Xu, J., Kennett, M. J., Durbin, R. K., Durbin, J. E., Tripp, R., Lamb, R. A. and He, B. (2007) Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge. Virology. 362(1):139-50.
   
6. Wilson, R. L., Fuentes, S. M., Wang, P., Taddeo, E. C., Klatt A., Henderson A. J. and He, B. (2006) Function of small hydrophobic proteins of paramyxovirus . J. Virol. 80(4):1700-9.
   
7. Lin, Y., Horvath, F., Aligo, J. A., Wilson, R. and He, B. (2005) The role of simian virus 5 V protein on viral RNA synthesis. Virology. 338(2):270-280.
   
8. Sun, M., Rothermel, T. A., Shuman, L., Aligo, J. A., Xu, S., Lin, Y., Lamb, R. A. and He, B. (2004) The conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis J. Virol. 78(10):5068-78.
   
9. Lin, Y., Bright, A. C., Rothermel, T. A. and He, B. (2003) Induction of apoptosis by paramyxovirus simian virus 5 lacking small hydrophobic gene. J. Virol. 77(6):3371-83.
   
10. He, B., Paterson, R. G., Stock, N., Durbin, J. E., Durbin, R. K., Goodbourn, S., Randall, R. E. and Lamb, R. A. (2002) Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: The multifunctional V protein blocks both interferon-b induction and interferon signaling. Virology, 303, 15–32.